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The aim of this review is to provide an extensive descriptive overview of studies published on this issue (including references to many reports in the last six decades which have historical interest)

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Rely on Symptoms To quote NEQAS: In the event of any discordance between clinical findings of B12 deficiency and a normal B12 laboratory result, then treatment should not be delayed

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Consequently, either extreme may upset the crucial redox balance needed for normal functional phenotypes in cells: too much or too little ROS will interfere with cell growth and survival